Captain Jonathan Toews and Duncan Keith also scored for the Blackhawks, who beat the NHL-leading Ducks for the third straight time at Honda Center. Corey Crawford made 21 saves as Chicago controlled the meeting of Western Conference powers, taking a three-goal lead in the second period.
Rickard Rakell scored with 9:54 to play and Frederik Andersen stopped 29 shots for the Ducks, who have back-to-back losses in two days after a six-game winning streak.
Shortly before Kane scored his first goal, Keith scored on what appeared to be goaltender interference by Toews during a dominant middle period by Chicago.
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