Jayla Oden, the only Illinois player to score in double figures, had 16 points on 6-of-10 shooting. The rest of the Illini shot just 27% (14 of 51) from the field.
Damaria Franklin led the Flames with 25 points, tying his career high.
This ends the Ramblers' 10-game winning streak.
Johnny Davis scored 27 points, and No. 8 Wisconsin beat Northwestern 82-76 on Tuesday night for its seventh straight win.
Luke Williamson made five 3-pointers and scored 15 points, and No. 22 Loyola Chicago won its 10th straight game, routing Evansville 77-48 on Tuesday night.
Sasha Stefanovic scored 22 points, including a go-ahead 3 at the start of double overtime that sent No. 4 Purdue over No. 17 Illinois 96-88 on Monday.
Brandon Betson scored 18 points and Chicago State defeated Lamar 67-56 on Saturday for the Cougars’ first conference road victory since the 2016-17 season.
Northwestern beat Michigan State at its game, crashing the offensive boards and hustling for loose balls to beat a top 10 team on the road for the first time in nearly five years.
Jalen Terry scored 28 points, David Jones added 24 and DePaul stunned No. 20 Seton Hall with a 96-92 victory on Thursday.
Trent Frazier scored a season-high 29 points, Kofi Cockburn had his eighth straight double-double with 16 points and 13 rebounds, and No. 25 Illinois held off struggling Nebraska for a hard-earned 81-71 victory Tuesday night.
The Wildcats trimmed the 12-point halftime deficit to six with 37 seconds left, but Ohio State held them off at the foul line.
The Blue Demons have lost 21 straight games to the Wildcats, dating back to 2008.
Kofi Cockburn posted his seventh straight double-double, Trent Frazier scored 16 points and Illinois rallied after squandering an early lead to beat Maryland 76-64 on Thursday night.
Ryan Schwieger scored 24 points on 9-of-10 shooting to lead Loyola Chicago past San Francisco 79-74 in an impromptu neutral-site matchup at Salt Lake Community College on Thursday.
Kofi Cockburn had 29 points, 10 rebounds and a season-high four blocks for his eighth double-double of the season and Illinois dominated Minnesota 76-53 on Tuesday night for its fourth straight win in the series.
Antonio Reeves had 24 points to pace the Redbirds (8-7, 1-1).
Boo Buie and Chase Audige had 12 points apiece for Northwestern.
Jahsean Corbett scored a season-high 26 points for the Cougars (4-11, 0-2), whose losing streak reached four games.
Javon Freeman-Liberty led DePaul with 22 points.
Peter Nance scored 15 points and Northwestern cruised past Division II Illinois-Springfield 90-50 on Monday night.