A night after tying the team's previous single-season loss mark, the Knicks dropped their seventh straight and 14th in 16 games.
Jimmy Butler scored 18 for Chicago.
The rookie Mirotic had another strong game, finishing five points shy of his career high. Gasol recorded his league-leading 48th double-double as Chicago won for the fifth time in six games.
The Bulls, who led by 20 at halftime, fell four points short of their most lopsided victory of the season. They pulled within two games of Central Division leader Cleveland and moved 1 1/2 games ahead of fourth-place Toronto in the Eastern Conference.
Andrea Bargnani led New York with 14 points and seven rebounds.
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