Liddell scored 17 points in the first five minutes, including a career-high five 3-pointers in that span.
He set a personal best in field goals made, finishing 12 of 20 from the field. His production helped Ohio State shoot 67% in the first half.
The Buckeyes led 51-39 at halftime and matched their scoring output from a 67-51 loss at Indiana on Thursday.
The Wildcats trimmed the 12-point halftime deficit to six with 37 seconds left, but Ohio State held them off at the foul line.