CHICAGO (AP) - Miscues missing during the Chicago Cubs' eight-game winning streak helped bring it to an end.
Brett Wallace hit a three-run homer in San Diego's four-run seventh inning, and the Padres stopped the Cubs' streak with a 7-4 victory on Wednesday in the opener of a day-night doubleheader.
The Cubs, who have the best record in the majors at 25-7, had been 18-2 this season when leading after six innings. But Pedro Strop (1-1) failed to retire any of the five batters he faced in the seventh and was charged with three runs and three hits. A throwing error also cost Chicago a run in the decisive half-inning.
"I felt really good about Strop but we didn't get the ground ball and didn't make the play," manager Joe Maddon said of Strop, who put two on before giving up Wallace's homer. "We just made some mistakes that we haven't been making."
Wil Myers had two hits and scored two runs for San Diego, which had lost three in a row. Carlos Villanueva (1-0) pitched a scoreless inning for the win, and Fernando Rodney got three outs for his ninth save.
Wallace is getting the chance to play every day and making the most of his opportunity.
"Offensively, you have to love his at-bats," Padres manager Andy Green said. "They're high quality, he takes his walks, he's got power and any time he can do something.
"As the year progresses and we finally get healthy, whenever that wonderful day comes, we'll find a way to get him on the field more often, whether it's at first base or third base. He's proven to be incredibly valuable in the lineup."
Ben Zobrist and Addison Russell each had two hits, but Chicago wasted a solid start by Kyle Hendricks.
The Padres got off to a fast start, pushing across two runs before Hendricks recorded an out. Travis Jankowski walked, stole second and scored on a throwing error by Cubs third baseman Javier Baez. Matt Kemp then singled in Myers to make it 2-0 in the first.
San Diego had runners on second and third when Jose Pirela grounded out for the final out of the inning, and Hendricks settled down from there. He allowed three runs, two earned, and six hits in 6 2/3 innings.
The Cubs got a run back in the bottom of the first on Anthony Rizzo's RBI single, and Zobrist tied it at 2 with a run-scoring single in the second.
Chicago then went in front with two runs in the fourth. Baez was hit by a pitch and scored from first when Russell followed with a double to right field. The next batter, backup catcher Tim Federowicz, doubled off the wall in left for a 4-2 lead.
Hendricks was pulled after a bunt single by Jankowski with two out in the seventh, and the Padres jumped all over Strop.
Jankowski advanced on a wild pitch and scored on a throwing error by Baez on an infield hit by Myers. Kemp walked and Wallace, the cleanup hitter, followed with a drive to left for his second of the season.
The Padres added an insurance run in the eighth on a sacrifice fly by Kemp.
Zobrist extended his hitting streak to nine games. He had reached in nine straight plate appearances — going back to Sunday — before flying out to deep center in the sixth.
Kemp, who went 1 for 3 with two RBIs, enjoys hitting at Wrigley Field. He has a .310 batting average (35-for-113) with 24 RBIs in 30 games in the ballpark.
Padres: RHP Andrew Cashner will miss his scheduled start on Friday with cramps in both hamstrings. Cashner was injured trying to score from first base in his last start on Sunday against the New York Mets.
Cubs: Maddon said C Miguel Montero (lower back tightness) could return from his rehab stint with Triple-A Iowa as early as this weekend.
RHP John Lackey (4-1, 4.02 ERA) goes for Chicago and San Diego sends LHP Drew Pomeranz (3-3, 2.12 ERA) to the mound for the second game of the doubleheader. Monday's scheduled series opener was rained out, leading to the doubleheader.