Bam Adebayo scored 16, and the hot-shooting Heat reached the 50-win mark for the first time since the 2013-14 season. Miami also increased its lead over second-place Milwaukee to 1 1/2 games and moved within a win of securing homecourt advantage in Round 1 of the postseason.
If the Heat go 3-1 the rest of the way, they'll clinch the top seed in the East.
Zach LaVine led Chicago with 33 points. DeMar DeRozan finished with 26.