Around 4:30 p.m., police say a 24-year-old and 25-year-old were sitting inside a vehicle in the 5100 block of South Hermitage Avenue when they were struck by gunfire.
The 24-year-old was shot in the legs and transported to an area hospital in critical condition, police said.
The 25-year-old was taken to a hospital in serious condition and later pronounced dead, police and the Cook County medical examiner's office said.
There were no offenders in custody, police said.
Detectives are investigating.