Officers responded to a report of a shooting involving multiple victims about 5 a.m. in the 800 block of Fletcher Drive, according to Wheeling police.
Police said two groups of people were involved in an altercation at a bar or restaurant in neighboring Prospect Heights earlier in the morning.
One of the groups returned to a residence on Fletcher Drive when it was fired upon by suspects from outside, police said.
Five people, between 28 and 30-years-old, were transported to area hospitals in various conditions, officials said.
Wheeling police continue to investigate.