Police say Teon Hemphill was last seen at his home in the 3300 block of North Neva Avenue at 3:50 p.m.
Hemphill is 5-foot-7 and weighs roughly 130 pounds. He was wearing a black hoodie, gray jogging pants, and white shoes when he was last seen.
He was carrying a black book bag and a black duffle bag.
Anyone with information about Teon's whereabouts is asked to contact Area Five Special Victims Unit at 312-746-6554.