Indiana State Police said the whole thing started with a minor crash at the Family Express on U.S. 231 in Crown Point.
The driver of that 2015 Chevy Equinox took off and got on I-65 going the wrong way.
The Equinox hit another car head-on. A third vehicle then crashed.
The driver of the Equinox and the driver they hit were dead at the scene.
The driver of the third car suffered non-life threatening injuries.