Illinois is coming off a bye, trying to get its offense going, possibly without starting quarterback Brandon Peters.
The Northwestern Wildcats will be seeking their first road win this season and their first win over the Michigan Wolverines since 2008.
Illinois linebacker Jake Hansen will miss the rest of the season after having knee surgery.
Illinois State (2-4, 0-3) crossed midfield just three times and got no than the NDSU 29.
Ryan Hilinski threw for 267 yards and two touchdown passes.
Wisconsin outgained Illinois 491-93 yards in total offense.
A pass interference penalty and Rocky Lombardi's 34-yard strike to Tyrice Richie on back-to-back plays gave the Huskies (4-2, 2-0) the ball at the Rockets' 7-yard line, setting the stage for John Richardson.
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It was the Huskers' most lopsided win in a Big Ten game since they joined the conference in 2011.
Chase Brown rushed for 257 yards and two touchdowns, the fourth best single-game rushing performance in Illinois history.
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Illinois has lost four in a row since beating Nebraska in the season opener.
Rocky Lombardi rushed for three touchdowns and threw for another.
Jack Coan, a Wisconsin transfer, left with an apparent left leg injury midway through the third quarter with the game tied at 10.
Evan Hull rushed for 216 yards and a pair of touchdowns
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The Blue Devils' defense forced Northwestern into punt or a turnover on its first seven drives.
The Wolverines (3-0) scored touchdowns on their first nine drives, eight of them on the ground.