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A personalized mRNA cancer vaccine from Moderna and Merck is showing promising results in a late-stage melanoma trial, reducing the risk of the cancer returning or spreading when combined with Keytruda.

Attorney General Kwame Raoul discusses Illinois’ lawsuit against the Trump administration over demands for personal information from millions of commercial drivers.

Get ready to pay more to drive in Illinois as the tollway board approves the largest passenegr toll hike in its history. 

The Athletic's Dan Wiederer joins Fox Chicago's Cassie Carlson to break down the biggest news out of Halas Hall as the Chicago Bears head to Cincinnati for crucial joint practice reps against Ja'Marr Chase, Tee Higgins, and the Bengals. The Bears' banged-up secondary is facing a massive test this week, especially rookie cornerback Malik Muhammad, who is stepping into the slot with Kyler Gordon still sidelined by a calf injury. Meanwhile, the left tackle battle has turned into absolute musical chairs as Braxton Jones returns to 1-on-1 reps, Theo Benedet moves sides, and Ozzy Trapilo looms in the shadows. Plus, we react to Marcus Davenport's arrival, D'Andre Swift's explosive camp, and whether starters should even play on Saturday night.

Called 'The liver of the river', Dupage county is set to release its fifty thousandth mussel into salt creek to continue their efforts to provide clean waterways to the county

CEO of consumer research company discuusses the effects of a mutli-billion dollar tariff refund on your bank account.

Supporters of Fr. Michael Pfleger gathered outside the Archdiocese of Chicago on Wednesday to call for his reinstatement at Saint Sabina Church.

Custodians in Cook County’s District 130 are set to lose their jobs in November as students, teachers and staff prepare to return to school.

Thousands of athletes are expected for Supertri Chicago this weekend, and a race coach shares last-minute tips and advice to help first-time competitors prepare for North America’s largest triathlon.

The Illinois Tollway Board of Directors voted unanimously Wednesday to approve toll increases for passenger and commercial vehicles beginning in the new year.

An epidemiologist explains what’s behind this mosquito season, what to know about Asian tiger mosquitoes and how you can protect yourself from bites and mosquito-borne illnesses.

Cook County’s second installment property tax bills are finally being sent out after a two-month delay, with homeowners now facing an Oct. 1 deadline and new guidance on how to appeal future assessments.

A new blood test is capable of detecting risk for Alzheimer's disease up to ten years in advance. 

FOX Chicago Bears reporter Devan Kaney breaks down the latest injuries, standout rookies, the Bears’ biggest challenges this season and Caleb Williams landing on the cover of Madden.

More than 84,000 NIPSCO customers remain without power after the Aug. 11 storms, with some Northwest Indiana communities facing outages until Aug. 25 as crews work to repair widespread damage.

The Illinois Tollway could soon vote on a proposed toll hike. Drivers are weighing in.

An emergency response was underway Wednesday morning on Chicago's South Side after a car crashed into a pole in Park Manor.

Chicago police are investigating several shootings that left one teenager dead and six others wounded across the city overnight.

Mike Caplan has your Chicago weather update!