Police say the victims were on the sidewalk in the 2300 block of West 18th Street around 3 a.m. when they were shot at.
The woman, 37, was transported to Mt. Sinai Hospital in critical condition with a gunshot wound to the face.
A 36-year-old man transported to an area hospital also with a gunshot wound to the face and was pronounced dead.
There is no one in custody. Area Three detectives are investigating.