Both Ross and Hoyer are vaccinated and are reportedly feeling well.
Bench coach Andy Green will manage the team while Ross is out, starting with Friday's matchup against the Pirates at Wrigley Field.
"We take COVID incredibly seriously around here," Green said. "We’re going to do a number of things and not just test his (Ross') close contacts. We’re going to try to reduce our time in the clubhouse over the coming week, to try to mitigate as much as humanly possible the spread of it."
Cubs President Jed Hoyer talks with manager David Ross at spring training on Feb. 25, 2021. (Armando L. Sanchez/Chicago Tribune/Tribune News Service via Getty Images)
The Cubs said Ross and Hoyer are following CDC and MLB protocols, which means they will be quarantined for a minimum of 10 days.
As of Friday morning, all players on the active roster were considered available for the afternoon game.
The Cubs have not yet reached the 85 percent vaccination threshold set by MLB for relaxation of COVID-19 protocols, the team said.
The Associated Press contributed to this report.