The Friars are off to their best start since the 2015-16 team won 14 of its first 15.
They grabbed a 25-point halftime lead on the way to their eighth straight win.
Justin Minaya and Jared Bynum each scored 12 points for the Friars.
Minaya grabbed a season-high 11 rebounds, and Bynum had seven assists.
The Friars made 8-15 3-pointers, and coach Ed Cooley earned his 299th win over 16 seasons at Fairfield and Providence.
Javon Freeman-Liberty led DePaul with 22 points.