A witness told police that a vehicle was traveling southbound in the 4300 block of South Archer Avenue when it lost control and crashed into a building, officials said.
Both victims, who were in their 20's, were transported to Mount Sinai Hospital where they were pronounced dead a short time later, police said. Their identities have not yet been released by the Cook County medical examiner's office.
CPD's Major Accidents unit is investigating.
No further information was immediately available.