The girl was inside the house in the 9800 block of South Throop Street about 2:20 a.m. when two males began firing into the home from outside, Chicago police said.
The girl sustained a graze wound to the buttocks and was transported by paramedics to Comer Children's Hospital, police said. She was reportedly in good condition.
No one is in custody and Area Two detectives are investigating.
She was the second child shot on the South Side over the weekend.