The fire started in the basement of a home around 1:30 a.m. in the 1800 block of South Hamlin Avenue, according to police.
A resident smelled smoke and alerted everyone to get out of the home, police said.
Everyone was able to safely exit the residence but a 73-year-old man was taken to a local hospital due to smoke inhalation, police said. He was listed in fair condition.
The Chicago Fire Department is investigating.