The 25-year-old was with an acquaintance inside a home around 2:10 a.m. in the 1500 block of West 94th Street when there was an altercation and a struggle ensued, police said.
The man was shot in the chest and pronounced dead at the scene, police said. No other injuries were reported.
The alleged gunman fled the home in an unknown direction, police said.
No one is in custody as Area Two detectives investigate.