Clinical trial offers hope for Dravet Syndrome patients
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It's a rare and severe form of epilepsy --- one that brings daily, debiliting seizures.  But. clinical trials for a first-of-its-kind treatment are underway -- and they're being led in part by a doctor at Lurie Children's.  Kasey Chronis is live downtown with details.

Former Notre Dame football coach Lou Holtz dies at 89
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A very sad day in the sports world as a Notre Dame legend passes away. Cassie Carlson joins us with the latest on the loss of a sports icon.

Two young unidentified Black girls found dead inside buried suitcases in Ohio

Police in Cleveland, Ohio, are asking the public for tips after two young Black girls were found dead inside separate suitcases buried in shallow graves on Monday.

Chicago mayor leads celebration as city marks 189 years
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Mayor Brandon Johnson kicked off Chicago’s 189th birthday with a celebration at Lookingglass Theatre, highlighting the city’s history, culture and growth from 4,000 residents in 1837 to nearly 2.7 million today.

Why is the U.S. at war with Iran? Expert explains
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Talking to kids about what’s happening in the Middle East --- it’s tough out.  But help is out there and his name is Ben Sheehan. He's the author of the children's book "What Does the Constitution Say," co-host of the "Ten News Children's Podcast" and host of the PBS show Civics Made Easy.

Senate fails to pass war powers resolution

In a vote Wednesday, the Senate failed to pass a war powers resolution which gives lawmakers an opportunity to demand congressional approval before any further attacks are carried out.

Americans struggle to get out of Middle East amid war
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The U.S. State Department is starting to get Americans out of the Middle East but some airspace in the region is still shut down.

US will strike 'deeper' in Iran as war spreads, officials say
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The White House said there are no plans to send group troops into Iran right now, but more forces are headed to the Middle East.

Nancy Guthrie disappearance: Day 32 latest updates

Wednesday marks Day 32 in the search for Nancy Guthrie, the 84-year-old mother of NBC "Today" show host Savannah Guthrie, who went missing from her Tucson-area home on Feb. 1. Authorities believe Nancy was taken from her home against her will.

Fire rips through North Park homeless encampment days before city clearance
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A late-night fire tore through a homeless encampment in Legion Park, destroying 15 tents and leaving residents who say they lost everything waiting for answers as the city prepares to clear the site on March 17.

Chicago police warn of fraudulent donation scheme

Chicago police are warning the public of a recent scam seeking donations after a tragic event in the South Loop and Near South Side.

Ald. Conway demands answers over Chicago debt repayment strategy | ChicagoLIVE
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Alderman Bill Conway calls on Mayor Brandon Johnson to explain why the administration’s reported debt strategy differs from a repayment scheduled previously shared with City Council. 

Chicago-area convenience store owner sentenced in WIC fraud scheme

A Chicago-area store owner has been sentenced in a yearslong scheme that defrauded a food assistance program for low-income women and children.

LSU transfer Tre People joins Chicago State Football | ChicagoLIVE
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Tre People, former LSU quarterback, is set to play for Chicago State University under first-ever head coach Bobby Rome II, marking a new chapter for the program. 

Hegseth says US submarine sank Iranian warship in international waters

The U.S. and Israel struck Tehran and other Iranian cities in airstrikes on the fifth day of the war with Iran. Here's what you need to know.