MILWAUKEE - Lauren Van Kleunen scored 22 points and Selena Lott scored 20 and Marquette beat No. 16-ranked DePaul 90-83.
Isabelle Spingola's layup with 7:21 remaining put Marquette ahead 76-54.
The Blue Demons rallied and outscored Marquette 24-7 over the next six minutes.
Lexi Held's 3-pointer with 1:23 remaining brought DePaul within 83-78, but Marquette made 5 of 6 foul shots and Van Kleunen's layup with 27 seconds to go ended the threat.
Held led DePaul with 25 points.
DePaul ends regular-season play with a two-game losing streak in which it surrendered an average of 83 points a game.