The first unsolved case is the shooting of a 12-year-old girl on March 1.
Video from that night showed three suspects with guns. Chicago Police need help finding them.
"Our officers refuse to let this become the norm. We are soliciting the public's help in this case," said CPD Superintendent David Brown at a Tuesday morning news conference.
The other case also ripped a family apart.
Christian Ruiz crashed his car on West Cermak after he was shot April 13 in Little Village. His three children were in the car and saw his murder.
"His children were not physically harmed but witnessed their father's murder," said Brown.
Also on Tuesday, Brown announced the police department recently paid out its first reward received from a homicide and drug trafficking tip line.
"This is anonymous and that's really important to encourage other people to come forward so the best we can do is highlight people are calling - number one. And a person has received the award, and we're not going any further to make sure no one is concerned about our revealing their anonymity," Brown said.
Though Brown didn’t give details, a solid tip in a murder case can mean a $5,000 to $15,000 reward.
The superintendent says murders and shootings are down in Chicago and they've cleared 105 homicide cases so far this year. But almost 160 people have been killed in the city in 2022.
Carjackings have ticked up in April, police said.
You can call the homicide and gun trafficking tip line at 833-408-0069 — or go to CPDTip.com.