The victims were in East Garfield Park in the 100 block of North Central Park Avenue at 1:20 a.m. when gunfire flew into the vehicle they were in.
A 39-year-old man was taken to Mt. Sinai Hospital in critical condition with a gunshot wound to the chest.
A 34-year-old woman was taken to the same hospital in good condition with a gunshot wound to the right hand.
No one is in custody. Area Four detectives are investigating.